The BIOMIMESYS® products are formed by crosslinking reaction of hydrosoluble modified Hyaluronic Acid (HA) and others extracellular matrix (ECM) components (collagens, fibronectin…)  with ADH (Adipic acid dihydrazide), to form the extra-cellular matrix.

In ECM, Hyaluronic acid (HA) is a key player which has different properties. This GAG has the properties to polymerise and thus made a solid scaffold which keeps the structure of the tissue. Furthermore, this component has different functions that binds to water molecules which allow water adsorption and that selectively bind different growth factor.

The fact that we have found a process to used hyaluronic acid as biopolymer to synthesis our 3D cell culture system allows us to keep all properties of hyaluronic acid and thus to reproduce at the best the ECM with all biological properties (same structure, cell adhesion, water stockage, signal reservoir …). Our BIOMIMESYS® technology is the only one on the market with these 2 properties, which are to be solid and to bind to water molecules and thus to allow water adsorption. It is because of these 2 properties, we called this 3D system : hydroscaffold.

Depending on the organ, extracellular matrix components are different and at various rates, allowing a more or less dense and compact cellular environment (different Elastic Modulus, porosity, …). BIOMIMESYS® 3D technology allows us to reproduce the cell environment of each organ.

All BIOMIMESYS® products

BIOMIMESYS® hydroscaffold 3D technology allows us to reproduce the cell environment of each organ.
 BIOMIMESYS® Adipose Tissue

BIOMIMESYS® Adipose Tissue

BIOMIMESYS® Adipose tissue is a biofunctionalized Hyaluronic Acid (HA) hydroscaffold with components of adipose tissue extracellular matrix: collagen I, collagen VI and the cell binding domain of fibronectin (RGDS)

BIOMIMESYS® Liver

BIOMIMESYS® Liver

BIOMIMESYS® Liver hydroscaffold is made of RGDS and galactosamine-grafted Hyaluronic acid, Adipic acid dihydrazide crosslinker and extracellular matrix (ECM) proteins (collagen type I and collagen type IV) to mimic liver-ECM composition.

BIOMIMESYS® Oncology

BIOMIMESYS® Oncology

BIOMIMESYS® Oncology is double interpenetrating network (IPN) hydroscaffold based on Hyaluronic acid (HA) and type I collagen crosslinked with Adipic acid dihydrazid (ADH)

BIOMIMESYS® Brain

BIOMIMESYS® Brain

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BIOMIMESYS® NASH

BIOMIMESYS® NASH

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BIOMIMESYS® Fibrotic Liver

BIOMIMESYS® Fibrotic Liver

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BIOMIMESYS® Custom

BIOMIMESYS® Custom

With our unique BIOMIMESYS® technology, we can develop a specific hydroscaffold ECM for each organ (healthy or pathologic)>, by fine tuning its elastic modulus and its composition.

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HCS Pharma Services

We can perform proof of concept / mechanism of action, assay development and primary or secondary screening for YOU.
Dermocosmetology

Dermocosmetology

HCS main assets for active cosmetic ingredients

Anti-Aging
Moisturizing
Wound healing
DNA damage protection assay
Cosmetics custom assays
Anti Inflammation
Sensitization

Pharmacology

Pharmacology

this technology allows phenotypic screening to discover new compounds and new targets for complex diseases, such as neurodegenerative diseases and cancer

Neurodegenerative diseases
Pharma custom assays
Oncology

Nutraceuticals

Nutraceuticals

Confirming the efficacy of nutraceuticals and functional food is a key for the development of new compounds. High content in vitro assays play a role in researching and developing new actives ingredients dedicated to human and animals food.

Inflammation assay
Oxidative stress assay
Lipidic peroxidation assay
Gut microbiota assay

Toxicology

Toxicology

Phenotypic screening by High Content Screening allows analysing toxic events, as genotoxicity, hepatotoxicity, neurotoxicity or cardiotoxicity at the early stage of research.

Hepatotoxicity
Neurotoxicity
Genotoxicity

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